twip's Podcast

October 2015
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Fri, 30 October 2015

The TWiP-lets reveal Balamuthia infection in the Children from Peru, and discuss resistance to pyrethroids revealed by RNA sequencing of Anopheles mosquitoes.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Links for this episode:

Balamuthia (CDC)
Pyrethroid resistance in Anopheles (Parasit Vectors)
Voltage-gated sodium channels
Pyrethroid (Wikipedia)
Image credit
Letters read on TWiP 98

Case study for TWiP 98

This week's case is a Professor clinician, teacher, researcher. In his 50s, he presents with lesion on big toe, anterior portion, tip, nodular. No surrounding redness, area is itchy. Has a small central black area the size of pencil tip, concerned because feels is getting larger over last week. Spooky. Travels, last in Brasil, had been for a few weeks, noticed toe issue a week after returned. Spent time on beach, but wore flip flops. Different types of beaches, crowded and not crowded. Went with wife. Healthy man, no prior medical problems.

Send your diagnosis to twip@twiv.tv

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv

Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Direct download: TWiP098.mp3
Category:Science -- posted at: 7:02pm PDT

Fri, 16 October 2015

TWiP 97: The seven year itch

The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Links for this episode:

Parasite Nobel Prizes 2015
Ivermectin story (Nat Rev Micro)
Ivermectin target (Brain Res)
Gut microbiota and Plasmodium protection (Cell)
Natural antibody (virology blog)
Image credit
Letters read on TWiP 97

Case study for TWiP 97

Daniel has two cases this week. Two people with similar presentations. A 12 yo girl in Peru presented for care with painless dark brown area on right knee. Has brothers and sisters, often play together. No trauma, but area is expanding. Months later develops cognitive changes. Second case is a 5 yo boy from the coastal region of Peru brought in by Mother, has red swollen area on face. Mom says while playing scratched nose, swelling right cheek, eye, nasal obstruction, no response to antibiotics. MRI of both show infiltrating process. Girl, left side of brain, middle cerebral artery territory. Boy in frontal region, midline area. Thus both skin lesions associated with infiltrating process in brain. Came into clinic months after lesions started, and lesions still present.

Send your diagnosis to twip@twiv.tv

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv

Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Direct download: TWiP097.mp3
Category:Science -- posted at: 8:38pm PDT

Sat, 3 October 2015

TWiP 96: Salivary pharmacopeia

The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Links for this episode:

Sandfly exposure and risk of cutaneous leishmaniasis (J Inf Dis)
TWiP 14: Leishmania
Image is L. longipalpis (credit)
Letters read on TWiP 96

Case study for TWiP 96

Daniel's patient for this week is male patient referred for consultation by OB-GYN: his wife is pregnant, has been admitted and is about the give birth. It is her first pregnancy. There are concerns about the husband's skin problem and whether it is a threat to his pregnant wife. No lesions on woman, husband recently developed itchy skin problem on his hands. Bilateral. Small papules on webs of fingers, brown lines, blood clots at ends, has clearly scratched the lesions. Skin between fingers is involved. Travels, often stays in cheap hotels. Beds not clean. Last trip 1 month before symptoms. Midwest travel. Family history of heart disease. Sales occupation. No animal exposure. Travels to medium to large cities.

Send your diagnosis to twip@twiv.tv

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv

Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Direct download: TWiP096.mp3
Category:Science -- posted at: 5:52am PDT