This Week in Parasitism
TWiP is a podcast about the tiny creatures that live in and on us.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

The TWiP trifecta solves the case of the Woman from Bolivia with Belly Pain, and discuss a method for population modification of malaria mosquitoes using a Cas9-mediated driver gene.

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Case study for TWiP 100

This week's case is a 27 yo female, native NY, referred to outpatient at CU after seeing OBGYN, told had seen worms in stool and underwear. Inch or two in length, pale white, round, moving, 2-3 weeks of constant abdominal bloating. Sexually active. No particular diet. Travel: works for NGO, refugee camp in Ethiopian-Sudan border, southern Sudan. Last visit month ago. Noticed worms when she got back from last trip. Eats what local people eat. Raw food popular there: kitfo, raw steak tartare, with melted butter. Made from local beef. Did not take malaria prophylaxis, did not avoid local water, does wear sandals. College graduate. Nothing remarkable in family. CBC, liver, metabolic: all normal. Stool not normal: loose, no mucus or blood.

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Direct download: TWiP100.mp3
Category:Science -- posted at: 9:16am PST

The TWiP trifecta solves the case of the Professor Who Went to Brazil, and discuss an amazing case of a tapeworm that turned into a tumor in an AIDS patient.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

 

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Case study for TWiP 99

This week's case is a 53 yo woman visiting family in US, comes in with intense belly pain, right upper part of belly. Has become strict vegetarian after having breast cancer, on raw vegetable diet (carrots, collect plants in local markets). From Bolivia. Lives in agricultural area, avoids sheep, fearful of dogs. Housekeeper. Married, lives with husband. Noticed pain when came to US. Breast cancer: localized, removed lesion, no therapy, months ago. No allergies, family healthy. No insect bites, lives in concrete house. Physical exam: not febrile, right upper quadrant is very tender, some liver enlargement. CBC: 10,000 white count, mostly eosinophils, liver function: AST, ALT, AlkPhos all normal. Neuro exam: normal. Five months before this diet, she did have normal diet. Some meat, drank milk.

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TWiP is a MicrobeTV production

Direct download: TWiP099.mp3
Category:Science -- posted at: 11:59am PST

The TWiP-lets reveal Balamuthia infection in the Children from Peru, and discuss resistance to pyrethroids revealed by RNA sequencing of Anopheles mosquitoes.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Case study for TWiP 98

This week's case is a Professor clinician, teacher, researcher.  In his 50s, he presents with lesion on big toe, anterior portion, tip, nodular. No surrounding redness, area is itchy. Has a small central black area the size of pencil tip, concerned because feels is getting larger over last week. Spooky. Travels, last in Brasil, had been for a few weeks, noticed toe issue a week after returned. Spent time on beach, but wore flip flops. Different types of beaches, crowded and not crowded. Went with wife. Healthy man, no prior medical problems.

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Direct download: TWiP098.mp3
Category:Science -- posted at: 7:02pm PST

The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

 

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Case study for TWiP 97

Daniel has two cases this week. Two people with similar presentations. A 12 yo girl in Peru presented for care with painless dark brown area on right knee. Has brothers and sisters, often play together. No trauma, but area is expanding. Months later develops cognitive changes. Second case is a 5 yo boy from the coastal region of Peru brought in by Mother, has red swollen area on face. Mom says while playing scratched nose, swelling right cheek, eye, nasal obstruction, no response to antibiotics. MRI of both show infiltrating process. Girl, left side of brain, middle cerebral artery territory. Boy in frontal region, midline area. Thus both skin lesions associated with infiltrating process in brain. Came into clinic months after lesions started, and lesions still present.

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Direct download: TWiP097.mp3
Category:Science -- posted at: 8:38pm PST

The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

 

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Case study for TWiP 96

Daniel's patient for this week is male patient referred for consultation by OB-GYN: his wife is pregnant, has been admitted and is about the give birth. It is her first pregnancy. There are concerns about the husband's skin problem and whether it is a threat to his pregnant wife. No lesions on woman, husband recently developed itchy skin problem on his hands. Bilateral. Small papules on webs of fingers, brown lines, blood clots at ends, has clearly scratched the lesions. Skin between fingers is involved. Travels, often stays in cheap hotels. Beds not clean. Last trip 1 month before symptoms.  Midwest travel. Family history of heart disease. Sales occupation. No animal exposure. Travels to medium to large cities. 

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Direct download: TWiP096.mp3
Category:Science -- posted at: 5:52am PST

Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for Leishmania infections.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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This episode is sponsored by ASMGAP.

Case study for TWiP 95

Daniel's patient for this week is a 28 yo single female, returns from beach vacation with new boyfriend. Two weeks in Central America (Belize). Often found secluded beaches. Good health, noticed upon her return had small nodules/papules on front of thighs. Thought were insect bites, became very itchy. Noticed serpiginous red lines forming, radiating out from bumps. Felt things moving in her skin. Benadryl did not help. Daniel say something similar occurs in Lima. Healthy, no allergies, surgeries, no relevant family history, using barrier contraception, sexually active. Only drinks alcohol socially. Boyfriend did not report symptoms. She did lie on sand, used thin fabric. Stayed in hotel. There were wild dogs on beach. During her stay she ate ceviche. No intestinal symptoms.

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Direct download: TWiP095.mp3
Category:Science -- posted at: 6:44pm PST

Vincent, Dickson, and Daniel solve the case about the man from El Salvador, discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Case study for TWiP 94

Daniel's patient was seen in the clinic. He is a 33 yo chinese male, from Chinatown NYC, for several months on and off has had watery diarrhea, headaches. Tried reflexology, chiropractic therapy, with no results. Has traveled quite a bit, been in Chile (was there a few months before). Came to US when young. Grew up in the US. In Chile, has had many sexual partners, >50, of both sexes, also has done many drugs. Two years ago was diagnosed with chronic HIV, CD4 count 685, on ARVs triple therapy, virus loads are well controlled. Has had syphilis, nose job, no medication allergies. Lives with family. On exam, afebrile, looks well. Symptom onset a few months after last Chile visit. Is an addventurous eater.

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Direct download: TWiP094.mp3
Category:Science -- posted at: 6:45am PST

Vincent, Dickson, and Daniel solve their fishy tale, and present a new case study for your consumption.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Case study for TWiP 92

 

April 2015 a 177 lb 5ft10in 39 yo man seen as outpatient in ID clinic, reports 2 y ago had issues with constipation on and off; throat hurts; feels closing when lies down. For several years has had skin irritation on upper chest and arms. Tried to donate blood, was rejected, told to see doctor.

Emigrated to US from El Salvador 2002, married, reports no extramarital sex, smokes 2-3 cigs/day, now quit; had drinking issue in past, no more; was agricultural worker in rural part of El Salvador; has history of asthma, on a number of medicines, including steriod nasal spray, inhaler, no visual problems, healthy appearing, not allergic to medicines. Family history: mother heart attack and diabetes; father peptic ulcer disease.

 

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Direct download: TWiP093.mp3
Category:Science -- posted at: 6:57am PST

Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

Links for this episode:

  • Ascaris on TWiP 21
  • Ascaris lumbricoides life cycle (jpg)
  • Child with distended abdomen due to Ascaris (jpg)
  • Bottlenecks and Chagas disease (Proc Biol Soc)
  • Letters read on TWiP 92

Case study for TWiP 92

A 20 yo Japanese female student went to the emergency room with severe abdominal pain. nausea, had vomited. Had just enjoyed homemade sushi an hour or two previuosly. She prepared the sushi: rice, salmon, tuna rolls. Salmon was local, caught by boyfriend. Tuna from store, sushi grade. No past medical history, mother with anemia. Takes oral contraceptives. No toxic habits. No travel. Monogamous. Temp 100.2, bp 140/90, hr high 90s, breathing upper teens. Physical exam normal except appears distressed in pain, belly extended, tender in left upper quadrant. Friends ate sushi but no one else got sick. All guests ate both types of fish.

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Direct download: TWiP092.mp3
Category:Science -- posted at: 5:44am PST

Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP091.mp3
Category:Science -- posted at: 5:26am PST

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP090.mp3
Category:Science -- posted at: 8:38am PST

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP089.mp3
Category:Science -- posted at: 8:40am PST

Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP088.mp3
Category:Science -- posted at: 7:57am PST

Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and present another mystery for your solving.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP087.mp3
Category:Science -- posted at: 8:55am PST

Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP086.mp3
Category:Science -- posted at: 6:18am PST

Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP085.mp3
Category:Science -- posted at: 7:17am PST

Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP084.mp3
Category:Science -- posted at: 7:12am PST

Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP083.mp3
Category:Science -- posted at: 4:59pm PST

Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP082.mp3
Category:Science -- posted at: 9:42am PST

Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP081.mp3
Category:Science -- posted at: 10:15am PST

 Vincent and Dickson welcome new TWiP host Daniel to discuss the association of a new Mycoplasma with Trichomoniasis, and to introduce a new feature to the show, a case study.

Hosts: Vincent RacanielloDickson Despommier, and Daniel Griffin

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Direct download: TWiP080.mp3
Category:Science -- posted at: 6:15pm PST

Vincent and Dickson discuss the spread of P. knowlesi in Malaysia, and how Leishmania parasites protect the sandfly gut from bacterial infection.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP079.mp3
Category:Science -- posted at: 7:30am PST

Vincent and Dickson discuss how malaria parasites induce odors in their rodent hosts that attract mosquitoes.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP078.mp3
Category:Science -- posted at: 5:23pm PST

Vincent and Dickson discuss the exchange of messenger RNAs between a parasitic plant and its hosts.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP077.mp3
Category:Science -- posted at: 7:25am PST

Vincent and Dickson discuss how infection of mice with helminths induces cytokines that reactivate a latent gamma-herpesvirus.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP076.mp3
Category:Science -- posted at: 1:25pm PST

Bobbi Pritt joins Vincent and Dickson to talk about directing a clinical parasitology laboratory and her weekly case reports at Creepy Dreadful Wonderful Parasites.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Bobbi Pritt

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Direct download: TWiP075.mp3
Category:Science -- posted at: 8:58am PST

Vincent and Dickson review a novel malaria vaccine candidate comprising a parasite protein involved in egress from red blood cells.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP074.mp3
Category:Science -- posted at: 6:20am PST

Vincent and Dickson discuss how nibbling of human cells by Entamoeba histolytica, a process called amoebic trogocytosis, contributes to cell killing and tissue invasion.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP073.mp3
Category:Science -- posted at: 8:19am PST

Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive.

Hosts: Vincent Racaniello and Dickson Despommier

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Direct download: TWiP072.mp3
Category:Science -- posted at: 6:37am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review the finding that urocanic acid in the skin is a chemoattractant for the parasitic nematode Strongyloides stercoralis.

Download TWiP #71 (60 MB .mp3, 84 minutes).

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Direct download: TWiP071.mp3
Category:Science -- posted at: 8:46am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss the finding of Gnathostoma nematodes in Asian swamp eels from US live markets and wild populations.

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Direct download: TWiP070.mp3
Category:Science -- posted at: 1:25pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss an increase in the altitude of malaria distribution in warmer years in the highlands of Colombia and Ethiopia.

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Direct download: TWiP069.mp3
Category:Science -- posted at: 5:56am PST

Hosts: Vincent Racaniello Dickson Despommier, and Sagi Shapira

Vincent, Dickson, and Sagi discuss evidence that the pathogen Trypanosoma brucei undergoes meiosis and sexual reproduction.

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Direct download: TWiP068.mp3
Category:Science -- posted at: 6:41am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson explain the genetic and molecular basis of drug resistance in Schistosoma mansonii.

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Direct download: TWiP067.mp3
Category:Science -- posted at: 9:10am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss reversible inhibitors of cruzipain as new drugs for treating Chagas disease.

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Direct download: TWiP066.mp3
Category:Science -- posted at: 10:53am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson consider the effects of climate change on parasitic diseases.

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Dickson's Pick

Neglected by Shelly Xie (YouTube)

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Direct download: TWiP065.mp3
Category:Science -- posted at: 6:42am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review three novel approaches to antimalarial chemotherapy.

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Direct download: TWiP64.mp3
Category:Science -- posted at: 1:54pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss evidence that the malaria parasite originated in gorillas.

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Direct download: TWiP063.mp3
Category:Science -- posted at: 5:27pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss the high diversity of malaria parasites in West African bats, and a vaccine against hookworm.

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Direct download: TWiP062.mp3
Category:Science -- posted at: 6:10pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review examples of paleoparasitology, the detection of parasites in archaeological material.

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Direct download: TWiP061.mp3
Category:Science -- posted at: 7:35am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss how infection with Toxoplasma gondii causes mice to lose their aversion to cat urine, even after the parasites have been cleared.

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Listener Pick

Blaine - The Worm Within

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Direct download: TWiP060.mp3
Category:Science -- posted at: 1:07pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson update the multistate outbreak of cyclosporiasis, discuss the avian malaria parasite P. lophurae, and review protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.

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Direct download: TWiP059.mp3
Category:Science -- posted at: 8:38am PST

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Cali Despommier

Vincent and Dickson update the multistate outbreak of cyclosporiasis, and Dickson reads a chapter from his new book.

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Direct download: TWiP058.mp3
Category:Science -- posted at: 7:28pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review a multistate outbreak of cyclosporiasis caused by the single-celled coccidian parasite Cyclospora cayetanensis.

The day after recording this episode, ProMedMail reported that the outbreak of cyclosporiasis had spread to Texas.

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Direct download: TWiP057.mp3
Category:general -- posted at: 8:35am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss Myxobolus cerebralis, the parasite that causes whirling disease of salmonids.

Links for this episode:

Listener Pick

Amanda - Pandemic: On the Brink

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Direct download: TWiP056.mp3
Category:Science -- posted at: 5:47am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson reveal how invasive harlequin ladybirds use biological weapons against their competitors.

Links for this episode:

Dickson's Pick

An Inordinate Fondess for Beetles by Arthur V. Evans, Charles L. Bellamy

Listener Pick

Jessie - Pandemic, the board game

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv

Direct download: TWiP055.mp3
Category:Science -- posted at: 7:59am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson consider a case history of a young man with Blastocystis hominis - is it causing his disease?

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Direct download: TWiP054.mp3
Category:Science -- posted at: 9:35am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters.

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Direct download: TWiP053.mp3
Category:Science -- posted at: 3:02pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review the life cycle and pathogenesis of the giant kidney worm, Dioctophyme renale.

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Direct download: TWiP052.mp3
Category:Science -- posted at: 12:46pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Anthony A. James

Special guest Anthony A. James joins Vincent and Dickson to discuss how mosquitoes can be genetically modified to control infectious diseases.

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Direct download: TWiP051.mp3
Category:Science -- posted at: 7:48am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito.

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Direct download: TWiP050.mp3
Category:Science -- posted at: 6:44am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss innate immune sensing of Toxoplasma gondii in mice, and heme metabolism in protozoan parasites.

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Direct download: TWiP049.mp3
Category:Science -- posted at: 7:50am PST

Hosts: Vincent RacanielloDickson Despommier, and Josef Sabo

Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins.

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Direct download: TWiP048.mp3
Category:Science -- posted at: 3:48pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review evidence that a virus of the protozoan parasite Trichomonas vaginalis may exacerbate disease.

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Direct download: TWiP047.mp3
Category:Science -- posted at: 7:20am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in Plasmodium falciparumusing zinc finger nucleases.

Right-click to download TWiP #46 (46 MB .mp3, 64 minutes).

Links for this episode:

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Send your questions and comments (email or mp3 file) to twip@twiv.tv.

Direct download: TWiP046.mp3
Category:general -- posted at: 6:52am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss Toxoplasma biology with Stanford University Professor John Boothroyd.

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Direct download: TWiP045.mp3
Category:Science -- posted at: 5:34pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson explain how a nematode manipulates cricket behavior and alters the food web of a stream.

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Direct download: TWiP044.mp3
Category:Science -- posted at: 3:31pm PST

Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes.

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Direct download: TWiP043.mp3
Category:Science -- posted at: 7:38am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson answer listener emails about Leishmania, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more.

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Direct download: TWiP042.mp3
Category:Science -- posted at: 1:40pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review medically important arthropods.

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Direct download: TWiP041.mp3
Category:Science -- posted at: 6:43pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss loaiasis caused by the filarial nematode Loa loa.

Right-click to download TWiP #40 (52 MB .mp3, 73 minutes).

Links for this episode:

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Direct download: TWiP040.mp3
Category:Science -- posted at: 5:58pm PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson review the biology and pathogenesis of the amoebae Naegleria fowlerii and Acanthamoeba castellani.

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Direct download: TWiP039.mp3
Category:Science -- posted at: 11:05am PST

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson tackle the backlog of listener email, then consider the life cycle and pathogenesis of Trichomonas vaginalis, the flagellated protozoan transmitted by sexual contact.

Links for this episode:

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Direct download: TWiP038.mp3
Category:Science -- posted at: 6:53pm PST

Vincent and Dickson discuss the life cycle and pathogenesis of Dracunculus medinensis, the filarial nematode that causes dracunculiasis, or Guinea worm disease.

Links for this episode:

Direct download: TWiP037.mp3
Category:Science -- posted at: 12:49pm PST

Vincent and Dickson review how gut bacteria help establish T. muris in the large intestine of mice.

Direct download: TWiP036.mp3
Category:Science -- posted at: 8:09am PST

Vincent and Dickson discuss control of malaria with their Columbia University colleague David Fidock.

Direct download: TWiP35.mp3
Category:Science -- posted at: 6:36pm PST

Vincent and Dickson discuss control of malaria and filariasis with the bacterial endosymbiont Wolbachia.

Direct download: TWiP034.mp3
Category:Science -- posted at: 10:57am PST

Vincent and Dickson review an in silico pipeline for identifying molecular mimicry candidate proteins in the genomes of parasites, and catch up on listener email.

Direct download: TWiP033.mp3
Category:Science -- posted at: 8:40am PST

Vincent and Dickson discuss immune evasion by the cruzain protease of T. cruzi, and novel tetraspanin antigens of S. japonicum.

Direct download: TWiP032.mp3
Category:Science -- posted at: 1:41pm PST

Vincent and Dickson discuss the promising results of a phase III trial of a malaria vaccine in African children.

Direct download: TWiP031.mp3
Category:Science -- posted at: 6:17pm PST

Vincent and Dickson have a broad-ranging conversation with Charles Knirsch of Pfizer, Inc. about how public-private partnerships can function to control and eliminate infectious diseases.

Direct download: TWiP030.mp3
Category:Science -- posted at: 9:15am PST

Vincent and Dickson converse with Peter Hotez about global health, vaccinology, and neglected tropical diseases.

Direct download: TWiP029.mp3
Category:Science -- posted at: 1:14pm PST

Vincent and Dickson discuss medical entomology with Robert W. Gwadz, Assistant Chief of the Laboratory of Malaria and Vector Research at NIAID.

Direct download: TWiP028.mp3
Category:Science -- posted at: 9:26am PST

Vincent and Dickson continue their discussion of trematodes, or flukes, which have a snail as a reservoir host.

Direct download: TWiP027.mp3
Category:Science -- posted at: 2:12pm PST

Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.

Direct download: TWiP026.mp3
Category:Science -- posted at: 7:14am PST

Vincent and Dickson review Wuchereria bancrofti, the nematode that causes lymphatic filariasis, also known as elephantiasis.

Direct download: TWiP025.mp3
Category:general -- posted at: 6:48pm PST

Vincent and Dickson discuss the life cycle and pathogenesis of Onchocerca volvulus, the vector-borne filarial nematode parasite that causes onchocerciasis, or river blindness.

Direct download: TWiP024.mp3
Category:Science -- posted at: 10:49am PST

Vincent and Dickson review the life cycle and pathogenesis of the world's most unusual parasite, Strongyloides stercoralis.

Direct download: TWiP023.mp3
Category:Science -- posted at: 1:40pm PST

Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necator americanus.

Direct download: TWiP022.mp3
Category:Science -- posted at: 6:52am PST

Vincent and Dickson review the biology and pathogenesis of Ascaris lumbricoides, one of the largest nematodes to infect humans.

Direct download: TWiP021.mp3
Category:Science -- posted at: 7:20pm PST

Vincent and Dickson continue their discussion of nematodes with the whipworm Trichuris trichiura.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

Contact

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Direct download: TWiP020.mp3
Category:Science -- posted at: 6:50pm PST

Vincent and Dickson move on to nematodes with a discussion of the pinworm Enterobius vermicularis.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

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Direct download: TWiP019.mp3
Category:Science -- posted at: 10:16am PST

Vincent and Dickson discuss the intracellular parasite Cryptosporidium, which causes diarrheal disease in most mammalian species.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

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Send your questions and comments (email or mp3 file) to twip@twiv.tv.

Subscribe (free)

Click here to receive an email notification when a new episode of TWiP is published.

Direct download: TWiP018.mp3
Category:Science -- posted at: 4:37am PST

Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histolytica.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv.

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Direct download: TWiP017.mp3
Category:Science -- posted at: 10:51pm PST

Vincent and Dickson review the life cycle and pathogenesis of the flagellated protozoan parasite Giardia lamblia.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

Direct download: TWiP016.mp3
Category:Science -- posted at: 7:06am PST

Vincent and Dickson discuss the life cycle and pathogenesis of the protozoan parasite Trypanosoma.

Host links: Vincent Racaniello and Dickson Despommier

Links for this episode:

  • Metacyclic trypanomastigote (jpg)
  • Tsetse fly (jpg)
  • T. brucei life cycle (jpg)
  • T. brucei parasitemia (jpg)
  • Kissing bug nymph (jpg)
  • T. cruzi life cycle (jpg)
  • Letters read on TWiP 15
  • Direct download: TWiP015.mp3
    Category:Science -- posted at: 10:45am PST

    Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite Leishmania.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

  • L. braziliensis life cycle (jpg)
  • L. donovani life cycle (jpg)
  • L. tropica life cycle (jpg)
  • L. major lesion (jpg)
  • Transgenic mosquito delivers Leishmania vaccine (thanks, Geoffrey)
  • Plasmodium falciparum accompanied human expansion out of Africa (thanks, Prasad)
  • Who speaks for the guinea worm? (thanks, Michael)
  • Letters read on TWiP 14
  • Direct download: TWiP014.mp3
    Category:Science -- posted at: 7:30pm PST

    Vincent and Dickson continue their discussion of the obligate intracellular protozoan Toxoplasma gondii with a consideration of the clinical consequences of infection and pathogenesis.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

  • Isopod fish parasites (thanks, Kevin!)
  • Farmscraper on Word Spy (thanks, Mitchell!)
  • Toxoplasma and personalities (thanks, Greg!)
  • Science podcast (July 2) on parasites and intelligence (transcript - thanks, Jim!)
  • Letters read on TWiP 13
  • Direct download: TWiP013.mp3
    Category:Science -- posted at: 7:00pm PST

    Vincent and Dickson introduce the obligate intracellular protozoan Toxoplasma gondii, one of the most successful parasites on earth.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

  • Global clinical burden of malaria (PLoS Medicine)
  • T. gondii sporulated oocysts (jpg)
  • T. gondii tachyzoites in parasitophorous vacuole (jpg)
  • T. gondii life cycle (jpg)
  • Insect bioterrorism conference (thanks, Don!)
  • Parasite of the Day (thanks, Douglas!)
  • World Science Festival
  • Letters read on TWiP 12
  • Direct download: TWiP012.mp3
    Category:Science -- posted at: 7:00pm PST

    Vincent and Dickson continue their discussion of malaria, with emphasis on clinical aspects of the disease.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

  • The quest for a malaria vaccine (Meet the Scientist 49)
  • Science issue on malaria and tuberculosis
  • Malaria pathogenesis (pdf)
  • Malaria pathogenesis (jpg)
  • Letters read on TWiP 11
  • Direct download: TWiP011.mp3
    Category:Science -- posted at: 11:00am PST

    Vincent and Dickson trace the life cycle of Plasmodium in a mosquito and in a human host.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    • Mosquito cycle - sporogany (jpg)
    • Plasmodium falciparum cycle (jpg)
    • Plasmodium vivax cycle (jpg)
    • Plasmodium falciparum ring forms and gametocytes in blood (jpg)
    • Plasmodium stages (jpg)
    • Letters read on TWiP 10
    Direct download: TWiP010.mp3
    Category:Science -- posted at: 7:00pm PST

    Vincent and Dickson move on to protozoan parasites with a discussion of the early history of malaria.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    Direct download: TWiP009.mp3
    Category:Science -- posted at: 7:20pm PST

    Dickson reads his story about sparganosis caused by the diphyllobothroid tapeworm Spirometra mansonoides.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    Direct download: TWiP008.mp3
    Category:Science -- posted at: 9:30am PST

    Vincent and Dickson continue their discourse on tapeworms, covering the fish and dog varieties.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    • FAT the enemy that is shortening your life is BANISHED. How? With sanitized tapeworms. Easy to swallow! (jpg).
    • D. latum life cycle (jpg)
    • D. latum adult (jpg)
    • Diphyllobothrim proglottid (jpg)
    • Diphyllobothrim bothria (jpg)
    • Coracidium hatching from egg (jpg)
    • Dog tapeworm life cycle (jpg)
    • The Alien lifecycle (jpg)
    Direct download: TWiP007.mp3
    Category:Science -- posted at: 7:30pm PST

    Vincent and Dick talk about the anatomy and life cycle of beef and pork tapeworms, and why House was wrong about neurocysticercosis.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    • Taenia saginata life cycle (jpg)
    • Taenia saginata adult (jpg)
    • Taenia saginata scolex (jpg)
    • Taenia saginata gravid proglottid (jpg)
    • Taenia solium life cycle (jpg)
    • Taenia solium adult (jpg)
    • Taenia solium scolex (jpg)
    • Facial cancer in Tasmanian devils (thanks PhogDog!)

    Science Picks

    Dickson Peace through vaccine diplomacy by Peter Hotez
    Vincent Parasite Rex by Carl Zimmer

    Direct download: TWiP006.mp3
    Category:Science -- posted at: 9:30pm PST

    Vincent and Dick discuss the nurse cell, a unique structure formed in the host muscle by Trichinella species.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    Weekly Science Picks

    Dickson Every Living Thing by Rob Dunn

    Direct download: TWiP005.mp3
    Category:Science -- posted at: 7:30pm PST

    Vincent and Dick trace the life cycle of Trichinella spiralis in an infected host.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    • Trichinella life cycle (jpg)
    • Newborn larva entering muscle cell (jpg)
    • Adult T. spiralis in columnar epithelial cell (jpg)
    • Adult female T. spiralis (jpg)
    • Infective first stage T. spiralis larva in Nurse cell in muscle tissue (jpg)
    • Adult female T. spiralis with fully formed larvae in uterus (jpg)
    • Adult male T. spiralis with claspers on tail (jpg)
    • Clinical correlations in trichinosis (jpg)
    • Letters read on TWiP #4

    Weekly Science Picks

    Dickson David Scharf's pictures of microbial life
    Vincent
    The Nobel Laureate Meetings at Lindau

    Direct download: TWiP004.mp3
    Category:Science -- posted at: 9:00am PST

    Vincent and Dick distinguish among intracellular and extracellular parasites, then discuss the history and general characteristics of Trichinella spiralis.

    Host links: Vincent Racaniello and Dickson Despommier

    Links for this episode:

    Weekly Science Picks

    Dickson The Doctor and the Devils

    Direct download: TWiP003.mp3
    Category:Science -- posted at: 3:30pm PST

    Vincent and Dick classify parasites according to whether or not they are transmitted by a vector, then consider the implications of long-lived parasites.

    Host links: Vincent Racaniello and Dickson Despommier

    Direct download: TWiP002.mp3
    Category:Science -- posted at: 5:30pm PST

    Vincent and Dick provide an overview of parasites and parasitism.

    Host links: Vincent Racaniello and Dickson Despommier

    Weekly Science Picks

    Dick The Black Cloud by Fred Hoyle
    Vincent Parasitic Diseases by Despommier et al.

    Direct download: TWiP001.mp3
    Category:Science -- posted at: 4:00am PST